منابع مشابه
Commentary: New View on Treatment of Drug Dependence
In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. In this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. However, no positive results obtain...
متن کاملDrug and Alcohol Dependence
BACKGROUND: Alcoholism is characterized by impaired decision-making (i.e., choosing intoxication in the face of mounting negative consequences). This impairment may involve a reduced brain response to the negative consequences of behavior, which supports an inclination to engage in risky behaviors. The feedback error-related negativity (F-ERN) is hypothesized to reflect the valence attached to ...
متن کاملDrug dependence in prisoners.
Subjects, methods, and results In 1988-9 we interviewed a random sample of 1751 men serving a prison sentence (5% of the population) about drug use in the six months before arrest. Dependence on a drug was defined as in the previous study. Drug users were asked about previous contact with treatment agencies and their current attitude towards treatment. A question about drug use within prison wa...
متن کاملDrug and Alcohol Dependence
Background: Cocaine use, abuse and dependence remains a pressing public health problem. Based on its mechanism of action, varenicline, an alpha4beta2 partial agonist seemed to be a likely candidate for treating cocaine dependence. Methods: Cocaine dependent participants (n = 37) were enrolled in a 9-week double-blind placebo controlled clinical trial. Varenicline was titrated up to a target dos...
متن کاملGenetics of drug dependence
Drug-dependence disorders (we focus here on cocaine, opioid, and nicotine dependence) are genetically influenced. Risk genes have been located based primarily on genetic linkage studies, and identified primarily based on genetic association studies. In this article we review salient results from linkage, association, and genome-wide association study methodologies, and discuss future prospects ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1964
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5416.1073